Mental Health Issues in Menopause

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Published

2023-07-17

DOI:

https://doi.org/10.54169/ijocp.v3i01.64

Keywords:

mental health, mood, cognition, menopause, sexual dysfunction

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Vol. 3 No. 01 (2023): Indian Journal of Clinical Psychiatry

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REVIEW ARTICLE

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Copyright (c) 2023 Dr Vivek Kumar, Dr. Asish Kumar , Prof (Dr) Vipul Singh

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Authors

  • Dr Vivek Kumar Senior Resident
  • Dr. Asish Kumar assistant professor
  • Prof (Dr) Vipul Singh Professor

Abstract

Menopause is an inevitable phase of life in women which comes with various physical and mental health issues. Middle age, specifically the fourth decade of life is the common age for the onset of menopause in which fluctuation in sex steroid hormones leads to physical as well as mental symptoms. More than 85% of women have reported Vasomotor symptoms in terms of hot flashes and night sweats which is one of the earliest symptoms, begins in the menopausal transition and gradually progresses and lasts around 5-6 years. Anxiety disorders are quite prevalent and most of the time comorbid with depression. Common presentation is usually in the form of generalized anxiety and Panic attack symptoms.  Mood swings, irritability, and anxiety symptoms are heightened in the menopausal transition. Cognitive impairment during menopausal transition and post-menopause such as disturbance in concentration and memory is very common at this age.

How to Cite

Kumar, V., Asish Kumar, & Vipul Singh. (2023). Mental Health Issues in Menopause. Indian Journal of Clinical Psychiatry, 3(01), 22–30. https://doi.org/10.54169/ijocp.v3i01.64

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Author Biographies

Dr Vivek Kumar, Senior Resident

Senior Resident in the Department of Psychiatry, Government Medical College Kannauj (Uttar Pradesh)

Dr. Asish Kumar , assistant professor

assistant professor in the department of Psychiatry, Government Medical College Kannauj (Uttar Pradesh)

Prof (Dr) Vipul Singh , Professor

Professor and Head of the Department of Psychiatry, Government Medical College Kannauj (Uttar Pradesh)

References

Vijayalakshmi S, Chandrababu R, Victoria LE. Menopausal transition among northern Indian women. Nitte Univ J Health Sci 2013;3:73-9.

Prasad JB, Tyagi NK, Verma P. Age at menopause in India: A systematic review. Diabetes Metab Syndr. 2021 Jan-Feb;15(1):373-377. doi: 10.1016/j.dsx.2021.01.013. Epub 2021 Jan 20. PMID: 33524647.

Harlow BL, Wise LA, Otto MW, et al. Depression and its influence on reproductive endocrine and menstrual cycle markers associated with perimenopause: the Harvard Study of Moods and Cycles. Arch Gen Psychiatry 2003;60(1):29–36.

Endocrinol Metab Clin North Am. 2015 September ; 44(3): 497–515. doi:10.1016/j.ecl.2015.05.001.

Zheng H, Harlow SD, Kravitz HM, et al. Actigraphy-defined measures of sleep and movement across the menstrual cycle in midlife menstruating women: Study of Women’s Health Across the Nation sleep study. Menopause. 2015; 22(1):66–74. [PubMed: 24845393]

Sherman S, Miller H, Nerukar L, et al. NIH State-of-the-Science Conference on Management of Menopause-Related Symptoms, March 21–25, 2005. Am J Med. 2005; 118(suppl 2):1–172.

Cirignotta F, Mondini S, Zucconi M, et al. Insomnia: an epidemiological survey. Clin Neuropharmacol 1985;8:S49–54.

Young T, Rabago D, Zgierska A, et al. Objective and subjective sleep quality in premenopausal, perimenopausal and postmenopausal women in the Wisconsin sleep cohort study. Sleep 2003;26:667–72.

Sharkey KM, Bearpark HM, Acebo C, et al. Effects of menopausal status on sleep in midlife women. Behav Sleep Med 2003;1:69–80.

The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. 1993. Geneva: World Health Organization.

Yadav V, Jain A, Dabar D, Goel AD, Sood A, Joshi A, Agarwal SS, Nandeshwar S. A meta-analysis on the prevalence of depression in perimenopausal and postmenopausal women in India. Asian J Psychiatr. 2021 Mar;57:102581. doi: 10.1016/j.ajp.2021.102581. Epub 2021 Feb 5. PMID: 33582315.

Freeman EW, Sammel MD, Lin H, et al. Associations of hormones and menopausal status with depressed mood in women with no history of depression. Arch Gen Psychiatry. 2006; 63:375–382. [PubMed: 16585466]

Bromberger JT, Matthews KA, Schott LL, et al. Depressive symptoms during the menopausal transition: the Study of Women’s Health Across the Nation (SWAN). J Affect Disord. 2007; 103:267–272. [PubMed: 17331589]

Kravitz HM, Schott LL, Joffe H, et al. Do anxiety symptoms predict major depressive disorder in midlife women? The Study of Women’s Health Across the Nation (SWAN) Mental Health Study (MHS). Psychol Med. 2014; 44(12):2593–2602. [PubMed: 24467997].

Freeman EW, Sammel MD, Lin H. Temporal associations of hot flashes and depression in the transition to menopause. Menopause. 2009; 16:728–734. [PubMed: 19188849]

Freeman EW, Sammel MD, Lin H, et al. Symptoms in the menopausal transition: hormone and behavioral correlates. Obstet Gynecol 2008;111(1):127–36.

Freeman EW, Sammel MD. Anxiety as a risk factor from menopausal hot flashes: evidence from the Penn Ovarian Aging Cohort. Menopause 2016;23(9):942–9.

Sullivan Mitchell, E.; Fugate Woods, N. Midlife women’s attributions about perceived memory changes: Observations from the Seattle MidlifeWomen’s Health Study. J. Womens Health Gend Based Med. 2001, 10,351–362. [CrossRef] [PubMed]

Kuh, D.; Cooper, R.; Moore, A.; Richards, M.; Hardy, R. Age at menopause and lifetime cognition: Findings from a British birth cohort study. Neurology 2018, 90, e1673–e1681. [CrossRef] [PubMed]

Geerlings, M.I.; Ruitenberg, A.; Witteman, J.C.M.; Van Swieten, J.C.; Hofman, A.; Van Duijn, C.M.; Breteler, M.M.B.; Launer, L.J. Reproductive Period and Risk of Dementia in Postmenopausal Women. JAMA 2001, 285, 1475. [CrossRef] [PubMed]

Gibbs RB. Estrogen therapy and cognition: a review of the cholinergic hypothesis. Endocr Rec. 2010; 31:224–253.

Singh, Nilanchali; Sharma, Pallavi; Mishra, Neha1,. Female Sexual Dysfunction: Indian Perspective and Role of Indian Gynecologists. Indian Journal of Community Medicine: Jul–Sep 2020 - Volume 45 - Issue 3 - p 333-337 doi: 10.4103/ijcm.IJCM_365_19

Dennerstein L, Dudly E, Burger H. Are changes in sexual functioning during midlife due to aging or menopause? Fertil Steril 2001;76:456–60.

Osborn M, Hawton K, Gath D. Sexual dysfunction among middle-aged women in the community. BMJ 1988;296:959–62.

Dennerstein L, Randolph J, Taffe J, et al. Hormones, mood, sexuality, and the menopausal transition. Fertil Steril 2002;77:S42–8.

Gracia CR, Sammel MD, Freeman EW, et al. Predictors of decreased libido in women during the late reproductive years. Menopause 2004;11(2):144–50.

Palacios S, Robar AC, Menendez C. Sexuality in the climacteric years. Maturitas 2002;43:S69–77.

Rosen RC, Taylor JF, Leiblum SR, et al. Prevalence of sexual dysfunction in women: results of a survey study of 329 women in an outpatient gynecological clinic. J Sex Marital Ther 1993;19:171–88.

Harlow, S. D., Gass, M., Hall, J. E., Lobo, R., Maki, P., Rebar, R. W., … De Villiers, T. J. (2012). Executive summary of the Stages of Reproductive Aging Workshop + 10: Addressing the unfinished agenda of staging reproductive aging. Menopause, 19(4), 387–395. https://doi.org/10.1097/gme.0b013e31824d8f40.

Williams, R. E., Kalilani, L., Dibenedetti, D. B., Zhou, X., Granger, A. L., & Fehnel, S. E. (2008). Frequency and severity of vasomotor symptoms among peri- and postmenopausal women in the United States. Climacteric: The Journal of the International Menopause Society, 11, 32–43. https://doi.org/10.1080/13697130701744696.

Prior, J. C. (2006). Perimenopause lost – reframing the end of menstruation. Journal of Reproductive and Infant Psychology, 24(4), 323–335. https://doi.org/10.1080/02646830600974071.

Rance NE, Dacks PA, Mittelman-Smith MA, Romanovsky AA, Krajewski-Hall SJ. Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: a novel hypothesison the mechanism of hot flushes. Front Neuroendocrinol. (2013) 34:211–27. doi: 10.1016/j.yfrne.2013.07.003

Sandoval-Guzman T, Stalcup ST, Krajewski SJ, Voytko ML, Rance NE. Effects of ovariectomy on the neuroendocrine axes regulating reproduction and energy balance in young cynomolgus macaques. J Neuroendocrinol. (2004) 16:146–53. doi: 10.1111/j.0953-8194.2004.01143.x

Prague JK, Roberts RE, Comninos AN, Clarke S, Jayasena CN, Nash Z, et al. Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet. (2017) 389:1809–20. doi: 10.1016/S0140-6736(17)30823-1

Shughrue, P.; Scrimo, P.; Merchenthaler, I. Estrogen binding and estrogen receptor characterization (ER_ andER_) in the cholinergic neurons of the rat basal forebrain. Neuroscience 2000, 96, 41–49. [CrossRef]

Maki, P.M. Estrogen e_ects on the hippocampus and frontal lobes. Int. J. Fertil. Women’s Med. 2005, 50, 67–71.

Tang, Y.; Janssen, W.G.; Hao, J.; Roberts, J.A.; McKay, H.; Lasley, B.; Allen, P.B.; Greengard, P.; Rapp, P.R.; Kordower, J.H.; et al. Estrogen replacement increases spinophilin-immunoreactive spine number in the prefrontal cortex of female rhesus monkeys. Cereb. Cortex 2004, 14, 215–223. [CrossRef] [PubMed]

Barnabei VM, Cochrane BB, Aragaki AK, Nygaard I, Williams RS, McGovern PG, et al. Menopausal symptoms and treatment-related effects of estrogen and progestin in the women's health initiative. Obstet Gynecol. 2005;105:1063–73. [PubMed] [Google Scholar]

Freedman RR. Physiology of hot flashes. Am J Hum Biol. 2001;13:453–64. [PubMed] [Google Scholar]

37. Barton DL, Loprinzi CL, Quella SK, Sloan JA, Veeder MH, Egner JR, et al. Prospective evaluation of Vitamin E for hot flashes in breast cancer survivors. J Clin Oncol. 1998;16:495–500. [PubMed] [Google Scholar]

38. Ziaei S, Kazemnejad A, Zareai M. The effect of Vitamin E on hot flashes in menopausal women. Gynecol Obstet Invest. 2007;64:204–7. [PubMed] [Google Scholar]

Koothirezhi R, Ranganathan S. Postmenopausal Syndrome. 2022 Apr 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 32809675.

Stuenkel CA, Davis SR, Gompel A, Lumsden MA, Murad MH, Pinkerton JV, et al. Treatment of symptoms of the menopause: An endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2015;100:3975–4011. [PubMed] [Google Scholar] [Ref list]

Pinkerton JV. Hormone Therapy for Postmenopausal Women. N Engl J Med. 2020 Jan 30;382(5):446-455. [PubMed: 31995690]

Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J, et al. Nonhormonal therapies for menopausal hot flashes: Systematic review and meta-analysis. JAMA. 2006;295:2057–71.

Suvanto-Luukkonen E, Koivunen R, Sundström H, Bloigu R, Karjalainen E, Häivä-Mällinen L, et al. Citalopram and fluoxetine in the treatment of postmenopausal symptoms: A prospective, randomized, 9-month, placebo-controlled, double-blind study. Menopause. 2005;12:18–26.

Loprinzi CL, Barton DL, Sloan JA, Novotny PJ, Dakhil SR, Verdirame JD, et al. Mayo clinic and north central cancer treatment group hot flash studies: A 20-year experience. Menopause. 2008;15:655–60.

Bordeleau L, Pritchard KI, Loprinzi CL, Ennis M, Jugovic O, Warr D, et al. Multicenter, randomized, cross-over clinical trial of venlafaxine versus gabapentin for the management of hot flashes in breast cancer survivors. J Clin Oncol. 2010;28:5147–52.

Loprinzi CL, Sloan J, Stearns V, Slack R, Iyengar M, Diekmann B, et al. Newer antidepressants and gabapentin for hot flashes: An individual patient pooled analysis. J Clin Oncol. 2009;27:2831–7. [PMC free article] [PubMed] [Google Scholar] [Ref list]

J.Z. Tal, S.A. Suh, C.L. Dowdle, S. Nowakowski, Treatment of insomnia, insomnia symptoms, and obstructive sleep apnea during and after menopause: therapeutic approaches, Curr. Psychiatry Rev. 11 (1) (2015) 63–83

Caretto M, Giannini A, Simoncini T. An integrated approach to diagnosing and managing sleep disorders in menopausal women. Maturitas. 2019 Oct;128:1-3. [PubMed: 31561815]

Tandon VR, Sharma S, Mahajan A, Mahajan A, Tandon A. Menopause and sleep disorders. J Mid-life Health 2022;13:26-33.

Endocrinol Metab Clin North Am. Author manuscript; available in PMC 2016 June 02.

Soares CN, Arsenio H, Joffe H, et al. Escitalopram versus ethinyl estradiol and norethindrone acetate for symptomatic peri- and postmenopausal women: impact on depression, vasomotor symptoms, sleep, and quality of life. Menopause. 2006; 13:780–786. [PubMed: 16894334]

Rapp, S.R.; Espeland, M.A.; Shumaker, S.A.; Henderson, V.W.; Brunner, R.L.; Manson, J.E.; Gass, M.L.; Stefanick, M.L.; Lane, D.S.; Hays, J.; et al. E_ect of estrogen plus progestin on global cognitive function in postmenopausal women: The Women’s Health Initiative Memory Study: A randomized controlled trial. JAMA 2003, 289, 2663–2672. [CrossRef] [PubMed]

Epperson CN, Pittman B, Czarkowski KA, et al. Impact of atomoxetine on subjective attention and memory difficulties in perimenopausal and postmenopausal women. Menopause. 2011; 18:542–548. [PubMed: 21293309]

De Diego-Adeliño J, Crespo JM, Mora F, Neyra A, Iborra P, Gutiérrez-Rojas L, Salonia SF. Vortioxetine in major depressive disorder: from mechanisms of action to clinical studies. An updated review. Expert Opin Drug Saf. 2022 May;21(5):673-690. doi: 10.1080/14740338.2022.2019705. Epub 2021 Dec 29. PMID: 34964415.

Jayasena CN, Alkaabi FM, Liebers CS, Handley T, Franks S, Dhillo WS. A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women. Clin Endocrinol (Oxf). 2019 Mar;90(3):391-414. [PubMed]

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