Clinical Profile and Sexual Dysfunction Among Patients Receiving Buprenorphine: A Cross-Sectional Study from an OST Centre in Kashmir.

Abstract

Background: Opioid dependence is a major public health concern in Kashmir, with increasing use of buprenorphine-based opioid substitution therapy (OST). Understanding the sociodemographic and clinical characteristics of patients in treatment is crucial for optimizing outcomes. This study was conducted to assess the clinical and sociodemographic profile of patients receiving buprenorphine at an OST centre, and to evaluate the prevalence and correlates of sexual dysfunction among them.

Methods: This hospital-based cross-sectional study included 102 patients on buprenorphine maintenance. Data were collected using a semi-structured proforma covering demographic details, opioid use characteristics, and treatment variables. Severity of dependence was assessed using the Severity of Dependence Scale. The Arizona Sexual Experience Scale was applied to 24 patients reporting sexual complaints.

Results: The mean age was 26.7 years, and 95.1% were male. Intravenous or combined routes were predominant (78.4%), and 44.1% were HCV positive. The mean SDS score was 10.08 ± 3.42, with 66.7% showing severe dependence. The mean buprenorphine dose was 3.89 mg/day. Among 24 patients assessed, 83.3% met ASEX criteria for sexual dysfunction. ASEX scores correlated positively with SDS (r = 0.422, p < 0.01) and duration of opioid use (r = 0.374, p < 0.05), but not with buprenorphine dose or duration on treatment.

Conclusion: Patients attending OST centres in Kashmir are predominantly young, male, and severely dependent, with high rates of injecting drug use and HCV infection. Sexual dysfunction is common and correlates with chronicity and severity of dependence. Integration of sexual health and HCV management within OST programs is recommended.